I've always heard the opposite - spay the females to reduce the risk of mammary tumors.renay said:It is important that you netuer the males rather than spay the females (or do all 4) because intact males will fight over the females whether they're spayed or not. I don't see why they couldn't coexist together. But as mentioned, it is important to make sure all i'm guessing it would be testosterone? will have left they're bodies so that they don't have any manly urges, so its not quite as simple as getting them neutered and beginning the intro right away.