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I don't see why not, there is research of diabetic rats benefiting from dragon fruit aka pitaya juice and extract. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140125/https://www.ncbi.nlm.nih.gov/pubmed/24919841 There seems to be no knowing if there are long term negative effects from rats eating it because you're right there doesn't seem to be any talk about it out there besides those couple studies. The skin should be washed if eaten as dragon fruit from the grocery store tends to have the usual pesticides accumulated on it.
 

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