Females are certainly energetic... they are smart too... so watch out. They are so much harder to keep track of during out time, even if you have gone through the effort to rat-proof things.
They will find every way possible to get up onto and out of whatever they are in/on/near.
You cannot let them leave your sight it seems. I would say, choose depending on your ability to keep an eye on them. Seriously. You have to be on your toes with females. I will give an example: One of ours would hop from the couch to me and then to my desk, but I turned my head for two seconds, and one of my expensive bookshelf speakers was destroyed by little rat teeth (she tore the foam off one of the woofers), but I did not know immediately because when I turned back around, she was enjoying the warmth of my computer monitor and acting like nothing was wrong.