I used to use Carefresh, but about 3 months ago swtiched to kaytee total comfort bedding only cuz it was cheaper. The only difference besides the price is the feel of it. Its alot softer than Carefresh and a bit finer too. Other than that, there both great types of bedding to use. Even tho it doesnt look like much is in the Total Comfort it does expand and lasts as long as the 40L of the CareFresh.