As a person who has had perpetual sinus issues after moving from a low elevation area to a higher elevation, I'd be wary of taking your rats. I'm not sure if their sinuses work in the same manner that ours do, but any congestion could be worsened by the change in pressure. The fact that they're also old and prone to myco flare ups could be a problem just for the fact that that's a very long drive and it could stress them out which could cause a flare up. Add that factor to the changed pressure at the end of the trip and I think you might be better off either finding a sitter for them or training your daughter to give them their meds properly. This is, of course, just my two cents and I do understand the urge to take them with you.